Thermo Fisher Scientific TANK Polyclonal Antibody
TANK 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot과 IHC(Paraffin)에 사용 가능. 합성 펩타이드(aa 150-200)를 항원으로 제작. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 150–200 of human TANK conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage buffer | Whole serum |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: TANK.
Target Information
TANK was initially identified as a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Ligand binding by surface receptors in the TNF receptor and Toll/IL-1 receptor families leads to formation of a TRAF/TANK complex that mediates activation of NF-kappa-B via kinases IKK-iota and TBK1. These proteins can form a complex with NEMO, which regulates Ikappa-B complex activity. This suggests that TBK1 and IKK-iota may also modulate other NF-kappa-B functions. At least two isoforms of TANK are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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