Thermo Fisher Scientific ITFG2 Monoclonal Antibody (OTI3E10), TrueMAB
ITFG2 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, ICC/IF, Flow Cytometry 등에 사용 가능. 인간 시료 반응성. 무보존제, 동결건조 형태로 제공되며 재구성 및 결합 실험에 적합. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3E10 |
| Immunogen | Full-length human recombinant protein of human ITFG2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
ITFG2 is a component of the KICSTOR complex involved in the amino acid-sensing branch of the TORC1 signaling pathway. It recruits the GATOR1 complex to lysosomal membranes, enabling interaction with GATOR2 and RAG GTPases. ITFG2 functions upstream of RAG GTPases and is essential for negative regulation of mTORC1 signaling in the absence of amino acids. Without the KICSTOR complex, mTORC1 remains constitutively localized to lysosomes and activated. This complex may also play a role in mTORC1 regulation by glucose.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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