Thermo Fisher Scientific TMEM173 Monoclonal Antibody (OTI2C8), TrueMAB
TMEM173(STING) 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 Flow cytometry에 적합. 고순도 Affinity chromatography 정제, 액상 형태로 제공되며 안정적 PBS/BSA/glycerol 버퍼에 보존. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C8 |
| Immunogen | Full length human recombinant protein of human TMEM173 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
STING is a 379 amino acid signaling protein that acts as a key component of innate immune signaling. It activates NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferons (IFN-alpha and IFN-beta), exerting a potent antiviral state.
STING may function as a translocon and is involved in transduction of apoptotic signals via its association with MHC-II, facilitating detection of intracellular viral RNA and B-form DNA. It mediates death signaling through activation of the ERK pathway.
STING is generally localized in the endoplasmic reticulum membrane, cell membrane, and mitochondrial outer membrane, and is ubiquitously expressed in most tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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