Thermo Fisher Scientific hnRNP M3-M4 Monoclonal Antibody (2A6)
Western blot, IHC, ICC, IP 등 다양한 응용에 적합한 hnRNP M3-M4 단일클론 항체. 인간, 생쥐, 토끼 등 여러 종에 반응. 비결합형 액상 형태로 제공되며, -20°C 이하에서 보관. 연구용으로 RNA 결합 단백질 분석에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:10–1:500 |
| Immunocytochemistry (ICC/IF) | 1:10–1:500 |
| Immunoprecipitation (IP) | 1:10–1:500 |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Pig, Rabbit, Rat |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A6 |
| Immunogen | M19 fusion protein containing full-length human protein (hnRNP M3-M4, UniProt ID: P52272-1, amino acids 1–730) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2120510 |
Product Specific Information
Suggested positive control: antigen standard for HNRNPM (transient overexpression lysate).
Target Information
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA-binding proteins that associate with nascent RNA polymerase II transcripts. They are involved in transcript-specific packaging and alternative splicing of pre-mRNAs. The M1–M4 proteins form a cluster of hnRNPs that bind to poly(G) and poly(U) RNA homopolymers in vitro and are members of the ribonucleoprotein consensus sequence family. These proteins feature a methionine- and arginine-rich hexapeptide repeat (MR motif) similar to that found in the 64 kDa subunit of cleavage stimulation factor, which participates in pre-mRNA 3'-end maturation. Homologous M proteins are present in various eukaryotes from yeast to humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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