Thermo Fisher Scientific VIM Monoclonal Antibody (OTI7F5), TrueMAB
Human Vimentin 단백질(aa 210-466)을 면역원으로 한 Mouse monoclonal antibody. Western blot에 적합하며, carrier-free 형태로 제공되어 conjugation 실험에 유용. Lyophilized 상태로 제공되며 PBS buffer(8% trehalose) 구성. 연구용 전용 제품.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7F5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 210–466 of human VIM produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It plays a role in intracellular protein transport between the nucleus and plasma membrane.
During early development, vimentin is co-expressed with desmin and later replaced by tissue-specific IFPs. Vimentin has been implicated in steroid synthesis regulation by acting as a storage network for cholesterol-containing lipid droplets.
Phosphorylation of vimentin by protein kinase leads to intermediate filament breakdown and cytoskeletal rearrangement, facilitating lipid droplet–mitochondria interactions and promoting steroid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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