Thermo Fisher Scientific KRAS Monoclonal Antibody (OTI4C6), TrueMAB

Applications

• Western Blot (WB): 1:2,000 dilution tested

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
It plays a key role in regulating cell proliferation and can promote oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner.
Mutations in the KRAS gene are associated with:

• Acute myelogenous leukemia
• Juvenile myelomonocytic leukemia
• Noonan Syndrome
• Gastric cancer
• Cardiofaciocutaneous syndrome 2

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.