Thermo Fisher Scientific KRAS Monoclonal Antibody (OTI4C6), TrueMAB
KRAS 단백질을 특이적으로 인식하는 마우스 단클론 항체. Western blot에 최적화되어 있으며, 재조합 인간 KRAS 단백질을 면역원으로 제작됨. 동결건조 형태로 제공되며, 고순도의 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C6 |
| Immunogen | Full length human recombinant protein of human KRAS produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
It plays a key role in regulating cell proliferation and can promote oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner.
Mutations in the KRAS gene are associated with:
- Acute myelogenous leukemia
- Juvenile myelomonocytic leukemia
- Noonan Syndrome
- Gastric cancer
- Cardiofaciocutaneous syndrome 2
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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