Thermo Fisher Scientific SAFB Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

This gene encodes a DNA-binding protein with high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). It is thought to attach chromatin loops to the nuclear matrix, though evidence varies on whether it is part of chromatin or the nuclear matrix. Scaffold attachment factors are a subset of nuclear matrix proteins that bind specifically to S/MAR. The encoded protein may act as a molecular base for assembling a transcriptosome complex near actively transcribed genes. It regulates heat shock protein 27 transcription, can act as an estrogen receptor co-repressor, and is a candidate gene for breast tumorigenesis. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.