Thermo Fisher Scientific SATB1 Polyclonal Antibody
SATB1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, Flow cytometry에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 동결건조 형태로 제공되며, 재구성 후 500 µg/mL 농도로 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.5–1 µg/mL |
| Flow Cytometry (Flow) | 1–3 µg/1×10⁶ cells |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived human SATB1 recombinant protein (Position: D638–D763) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2747069 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
SATB1 (DNA-binding protein SATB1) is a crucial silencing factor involved in X inactivation mediated by Xist RNA during embryogenesis and in lymphoma. It binds to special AT-rich DNA sequences and nuclear matrix-associated regions, recognizing the sugar-phosphate structure of double-stranded DNA.
SATB1 acts as a transcriptional repressor controlling nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner by binding to matrix attachment regions and inducing local chromatin-loop remodeling.
It modulates genes essential for T-cell CD8SP maturation from thymocytes. SATB1-binding sites and Alu-like motifs form a chromatin context preferentially targeted by HIV-1 integration machinery. HIV-1 Tat may overcome SATB1-mediated repression of IL1 and IL2RA in T-cells by binding to the same domain as HDAC1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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