Thermo Fisher Scientific C5AR1 Monoclonal Antibody (S5/1)
C5a 수용체(CD88)를 인식하는 마우스 모노클로날 항체로, 인간 시료에 반응합니다. IHC(P), Flow Cytometry, Functional Assay에 사용 가능합니다. 단백질 A로 정제된 액상 항체이며, PBS 버퍼에 보존제를 포함하지 않습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Flow Cytometry (Flow) | 1:25–1:200 | |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S5/1 |
| Immunogen | C5aR peptide: Met1–Asn31 (C5AR1, UniProt ID: P21730-1, Human) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745080 |
Additional Formats
Product Specific Information
Mouse anti-Human CD88 antibody, clone S5/1 recognizes the C5a receptor (C5aR, CD88), which is predominantly expressed on cells of the myeloid lineage.
Target Information
CD88, also known as C5aR1, is a C5a anaphylatoxin receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma and is expressed in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract.
CD88 functions as the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, and superoxide anion production. It is part of the classical complement pathway and may be involved in tissue injury associated with ischemia or sepsis, as well as the membrane attack complex.
Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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