Thermo Fisher Scientific Calcitonin Receptor Monoclonal Antibody (31/01-1H10-4-1-14)
인체 Calcitonin Receptor를 인식하는 Mouse monoclonal antibody입니다. Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 적합합니다. 단백질 A로 정제된 액상형 항체로, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 31/01-1H10-4-1-14 |
| Immunogen | Synthetic peptide (DIPIYICHQELRNEPANN) derived from cytoplasmic domain of human calcitonin receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | <0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745083 |
Product Specific Information
Mouse anti-Human calcitonin receptor antibody, clone 31/01-1H10-4-1-14, recognizes the human calcitonin receptor — a membrane protein with seven transmembrane domains coupled to G protein messenger systems.
Target Information
The Calcitonin Receptor inhibits bone resorption and is expressed during development, playing roles in morphogenesis.
Three alternatively spliced receptor isoforms have been identified.
In addition to binding calcitonin, the receptor can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes.
Expression has been reported in artery, blood, bone, brain, kidney, lung, placenta, prostate, skeletal muscle, and thyroid. ESTs have been isolated from bone, embryo, kidney, and melanocyte/uterus/fetal heart libraries.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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