Thermo Fisher Scientific Phospho-PAX2 (Ser393) Polyclonal Antibody
Phospho-PAX2 (Ser393) 폴리클로날 항체로, 인간과 생쥐 시료에서 PAX2 인산화 단백질 검출에 적합합니다. Western blot에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 4°C 단기 보관, -20°C 장기 보관 권장.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Positive Control: HCT116, HCT116 nuclear extract
- Predicted Reactivity: Mouse (100%), Rat (100%), Sheep (100%)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of mouse PAX2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.57 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2792895 |
Product Specific Information
- Keep as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
- Predicted reactivity: Mouse (100%), Rat (100%), Sheep (100%).
- Positive Control: HCT116, HCT116 nuclear extract.
- Store product as a concentrated solution.
Target Information
The pax genes are a family of transcription factors active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box, enabling them to regulate gene expression.
Several pax genes are associated with developmental mutations:
- pax-3: linked to Waardenburg syndrome
- pax-6: linked to Aniridia
- pax-2: linked to Wilms tumor
During embryogenesis, Pax-2 is expressed in the developing kidney, particularly in condensing metanephric mesenchyme and early epithelial structures derived from mesenchyme. Pax-2 mRNA and protein levels decrease as tubular epithelium matures. However, Pax-2 expression persists in the undifferentiated epithelium of Wilms’ tumors, correlating with proliferation of poorly differentiated epithelial cells. Expression of the Wilms’ tumor suppressor protein WT1 coincides with down-regulation of pax-2, suggesting WT1 may directly repress pax-2 transcription.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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