Thermo Fisher Scientific Phospho-PAX2 (Ser393) Polyclonal Antibody
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
PA585758 | - | Thermo Fisher Scientific PA585758 Phospho-PAX2 (Ser393) Polyclonal Antibody 100 ul pk | 재고문의 | pk | 660,000원 | - | 726,000원 |
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Applications
Tested Dilution
Publications
Western Blot (WB)
1:500-1:3,000
Product Specifications
Species Reactivity
Human, Mouse
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of mouse PAX2.
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
1.57 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2792895
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Sheep (100%).
Positive Control: HCT116, HCT116 nuclear extract.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilmstumors. Persistent expression of Pax-2 in Wilms
tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms` tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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