Thermo Fisher Scientific Alpha-1-Antichymotrypsin (SERPINA3) (Histiocytoma Marker) Monoclonal Antibody (AACT/1451, AACT/1452)
Alpha-1-Antichymotrypsin(SERPINA3) 단백질을 표적하는 단클론 항체로, 사람 시료에 반응하며 IHC(P), IHC(PFA) 실험에 적합합니다. Alzheimer’s disease 연구 등에서 히스티오시토마 마커로 활용됩니다. 단백질 A/G 정제, 액상형, 4°C 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AACT/1451, AACT/1452 |
| Immunogen | Recombinant human Antichymotrypsin (AACT) protein fragment (around aa 49–187) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
SERPINA encodes Alpha 1-ACT, an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1-ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer’s disease (AD) and in normal aged human and monkey brain. Regulation of serine proteases and their inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to Alpha-1-ACT.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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