Thermo Fisher Scientific ALK Monoclonal Antibody (OTI22F2), TrueMAB
인간 ALK 단백질에 특이적인 Mouse IgG1 단클론 항체로 Western blot에 적합합니다. Lyophilized 형태로 제공되며, PBS/trehalose buffer에 보존됩니다. 뇌 발달 및 종양 관련 ALK 연구용으로 사용됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI22F2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) is a member of the insulin receptor superfamily and plays a crucial role in brain development.
Mutations, rearrangements, and amplifications of the ALK gene are associated with several tumors, including:
- Anaplastic large cell lymphoma
- Neuroblastoma
- Non-small cell lung cancer
Chromosomal rearrangement often leads to the NPM-ALK fusion gene, which exhibits oncogenic properties.
ALK is a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
It is essential for neuronal development and function within the nervous system.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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