Thermo Fisher Scientific ALK Monoclonal Antibody (OTI22F2), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) is a member of the insulin receptor superfamily and plays a crucial role in brain development.
Mutations, rearrangements, and amplifications of the ALK gene are associated with several tumors, including:

• Anaplastic large cell lymphoma
• Neuroblastoma
• Non-small cell lung cancer

Chromosomal rearrangement often leads to the NPM-ALK fusion gene, which exhibits oncogenic properties.
ALK is a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
It is essential for neuronal development and function within the nervous system.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.