Thermo Fisher Scientific ALK Monoclonal Antibody (OTI2D5), TrueMAB

Applications

Tested Application

• Western Blot (WB)

Recommended Dilution

• 1:2,000

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
• For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors, including:

• Anaplastic large cell lymphoma
• Neuroblastoma
• Non-small cell lung cancer

Chromosomal rearrangements often result in the NPM-ALK fusion gene, which produces an oncogenic protein.
ALK is a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
It plays a key role in neuronal development and function.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.