Thermo Fisher Scientific Axl Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:10,000
• Publications: [References unavailable]

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000
• Publications: [References unavailable]

Product Specifications

Product Specific Information

• Positive Control: human AXL-transfected 293T
• Predicted Reactivity: Mouse (85%), Pig (81%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma.
The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors such as vitamin K-dependent protein growth-arrest-specific gene 6 (GAS6), and is involved in the stimulation of cell proliferation.

TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors exhibit degenerative phenotypes due to inefficient removal of apoptotic cells and develop severe autoimmune symptoms similar to systemic lupus erythematosus, including production of broad-spectrum autoantibodies.

AXL may also function as a putative entry receptor for filoviruses and is used to identify Siglec 6+/Axl+ dendritic cells in human blood. Cellular expression of Axl can be upregulated by TLR ligands such as LPS or poly I:C. Soluble Axl is generated by proteolytic cleavage of its membrane form, and increased plasma levels may indicate inflammation or cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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