Thermo Fisher Scientific RORB Monoclonal Antibody (OTI1B6), TrueMAB
Human RORB 단백질(aa 1–260)에 특이적인 Mouse IgG1 단클론 항체로, Western blot에 최적화됨. 동결건조 형태로 제공되며 PBS 기반 완충액에 8% trehalose 포함. 신경계 발달 및 생체 리듬 연구용으로 적합.
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Thermo Fisher Scientific RORB Monoclonal Antibody (OTI1B6), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–260 of human RORB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Retinoid-related orphan receptor beta (RORβ), a NR1 thyroid hormone receptor, influences central nervous system development and function, including sensory integration and circadian rhythm regulation.
Disruption of RORβ in mice leads to juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed male fertility onset.
RORβ binds monomeric response elements containing the sequence AnnTAGGTCA.
An alternatively spliced isoform, RORβ2, is expressed in the pineal gland and retina, sharing DNA- and ligand-binding domains with wild-type RORβ but differing in the amino-terminal domain.
RORβ expression is documented in various regions of the mouse brain.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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