Thermo Fisher Scientific Neurotrypsin Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
GTVEVYASGV WGTVCSSHWD DSDASVICHQ LQLGGKGIAK QTPFSGLGLI PIYWSNVRCR GDEENILLCE KDIWQGGVCP QKMAAAVTCS FS

Sequence identity:
Highest antigen sequence identity to the following orthologs:

• Mouse: 42%
• Rat: 43%

Target Information

Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.