Thermo Fisher Scientific MPP10 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MPP10 protein. Validated for IHC(P) and ICC/IF applications. High specificity with recombinant immunogen and affinity-purified for reliable research results. Suitable for nucleolar protein localization and rib...
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MPP10. Recombinant protein control fragment (Product #RP-102647) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644078 |
Product Specific Information
Immunogen sequence:
RLTLDHEKSK LSLAEIYEQE YIKLNQQKTA EEENPEHVEI QKMMDSLFLK LDALSNFHFI PKPPVPEIKV VSNLPAITME EVAPVSVSDA ALLA
Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 97%
Target Information
MPP10 (M-phase phosphoprotein 10), also known as MPHOSPH10, is a 681 amino acid protein that localizes to the fibrillar region of the nucleolus. It is phosphorylated in the M phase of the cell cycle and forms part of the 60–80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex, essential for early cleavages during pre-18S rRNA processing. MPP10 interacts with IMP-3 and IMP-4 to form a heterotrimeric complex required for nucleolar association. The MPP10 gene is located on human chromosome 2, which contains over 500 genes. Mutations in genes on chromosome 22 are linked to disorders such as Phelan-McDermid syndrome, Neurofibromatosis type 2, autism, and schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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