Thermo Fisher Scientific MPP10 Polyclonal Antibody
Thermo Fisher Scientific의 MPP10 폴리클로날 항체로, 인간 MPP10 단백질을 인식합니다. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MPP10. Recombinant protein control fragment (Product # RP-96066) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644079 |
Product Specific Information
Immunogen sequence:
DDDLQENEDN KQHKESLKRV TFALPDDAET EDTGVLNVKK NSDEVKSSFE KRQEKMNEKI ASLEKELLEK KPWQLQGEVT AQKRPENSLL EETLHFDHAV R
Highest antigen sequence identity to the following orthologs:
- Mouse: 85%
- Rat: 83%
Target Information
MPP10 (M-phase phosphoprotein 10), also known as MPHOSPH10, is a 681 amino acid protein that localizes to the fibrillar region of the nucleolus. It is phosphorylated in the mitotic (M) phase of the cell cycle and is a component of the 60–80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. MPP10 is required for early cleavages during pre-18S rRNA processing and forms a heterotrimeric complex with IMP-3 and IMP-4, which may be essential for nucleolar association.
The gene encoding MPP10 is located on human chromosome 2, which contains over 500 genes. Mutations in genes on this chromosome are associated with Phelan-McDermid syndrome, Neurofibromatosis type 2, autism, and schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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