Thermo Fisher Scientific CXCR4 Polyclonal Antibody

Applications

• Western Blot (WB): Assay-dependent
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Product Specifications

Product Specific Information

A suggested positive control for this product is HeLa cell lysate.

Target Information

CXCR4 (also known as Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains. It functions as a co-receptor for X4 HIV-1 entry into CD4+ cells and also for HIV-2 binding through envelope glycoprotein gp120, promoting Env-mediated fusion.
CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1, which increases intracellular calcium ion levels and enhances MAPK1/MAPK3 activation. It also acts as a receptor for extracellular ubiquitin, leading to enhanced intracellular calcium and reduced cAMP levels.
CXCR4 plays essential roles in hematopoiesis, cardiac ventricular septum formation, and gastrointestinal tract vascularization by regulating vascular branching and remodeling. In the CNS, it mediates hippocampal neuron survival and cerebellar development.
CXCR4 binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory responses, including TNF secretion by monocytes. Antibodies to CXCR4 can block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and second extracellular loop serve as HIV binding sites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.