Thermo Fisher Scientific BUBR1 Polyclonal Antibody
Mouse BUBR1 단백질을 인식하는 Sheep 유래 Polyclonal 항체로 Western blot 및 Immunohistochemistry에 사용 가능. Recombinant protein(232-603 residues) 기반 면역원으로 제작. PBS buffer에 0.08% sodium azide 포함, -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Assay-dependent
Immunohistochemistry (IHC)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to residues 232–603 of mouse Bub1b |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2259239 |
Product Specific Information
A suggested positive control for this product is mitotic NIH-3T3 cells.
Target Information
BUBR1 is a member of the Ser/Thr protein kinase family and a key component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. Defects in spindle checkpoint function can lead to genetic instability and malignant transformation.
Human cells contain two related checkpoint kinases derived from the BUB1 gene: hBUBR1 and hBUB1. Both monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression, preventing premature entry into anaphase.
BUBR1 has been detected in human cancers and identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), potentially accelerating breast cancer progression through checkpoint inactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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