Thermo Fisher Scientific ICAD Polyclonal Antibody
ICAD 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에서 35 및 45kDa 밴드를 검출합니다. 휴먼 반응성, Rabbit IgG 호스트, 액상 형태로 제공되며, 냉장 또는 냉동 보관 가능합니다. 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): 1:1,000–1:2,000
- Suggested positive control: Jurkat cell lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids 2–21 of human DFF45 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | 2–8°C for up to 3 months; long-term at -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152553 |
Product Specific Information
In Western blot applications, this antibody detects bands at approximately 35 and 45 kDa in non-apoptotic cells. Jurkat cell lysate is recommended as a positive control.
Target Information
ICAD (Inhibitor of Caspase-Activated DNase) regulates nuclear apoptosis by inhibiting CAD (Caspase-Activated DNase).
It has two isoforms:
- ICAD-L/DFF45 (45 kDa) – functional isoform
- ICAD-S/DFF35 (35 kDa) – non-functional isoform
ICAD is cleaved by caspase-3 at residues 117 and 224, releasing fragments that activate CAD to fragment nuclear DNA during apoptosis.
Beyond its inhibitory role, ICAD serves as a folding chaperone for CAD.
ICAD is considered a potential therapeutic target for restoring normal apoptotic signaling in colon and brain cancer cells.
Two alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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