Thermo Fisher Scientific CD105 (Endoglin) Monoclonal Antibody (SN6), eBioscience

Applications and Tested Dilution

Product Specifications

Available Conjugated Formats

• APC
• APC-eFluor 780
• Brilliant UV 661
• eFluor 450
• Functional Grade
• PE
• PE-Cyanine7
• Super Bright 436
• Super Bright 600
• Super Bright 645
• Request custom conjugation

Product Specific Information

Description:
The SN6 monoclonal antibody reacts with human CD105 (Endoglin), a ~90 kDa disulfide-linked homodimer expressed by vascular endothelial cells, bone marrow cells, and activated macrophages. CD105 is involved in cell adhesion and embryonic angiogenesis.

Applications Reported:
Suitable for flow cytometric analysis.

Applications Tested:
Validated for flow cytometric analysis of U937 cell line. Recommended usage ≤1 µg per test (100 µL final volume). Cell number range: 10⁵–10⁸ cells/test. Titrate for optimal performance.

Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD105 (Endoglin) is a Type I transmembrane protein highly expressed on human vascular endothelial cells. It exists as an O- and N-glycosylated homodimer. Endoglin expression is upregulated in tumor vasculature and proliferating cells, serving as a proliferation-associated endothelial marker. It binds TGF-β1 and TGF-β3 with high affinity but not TGF-β2.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.