Thermo Fisher Scientific Periostin Monoclonal Antibody (OTI1A1), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked, secreted protein that binds heparin and functions as a ligand for α(V)β(3) and α(V)β(5) integrins.
It acts as a cell adhesion molecule in preosteoblasts, contributing to osteoblast recruitment, spreading, and attachment.
Periostin is mainly detected in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, but is upregulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGFβ1).
The protein contains a signal sequence, a cysteine-rich domain, four fasciclin-like repeats, and a C-terminal domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.