Thermo Fisher Scientific HIF-1 beta Recombinant Rabbit Monoclonal Antibody (ST05-25)
Recombinant rabbit monoclonal antibody targeting human HIF-1 beta (ARNT). Validated for WB and IHC applications. High specificity and lot-to-lot consistency. Supplied unconjugated in liquid form, suitable for research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ST05-25 |
| Immunogen | Recombinant protein within Human HIF-1 beta aa 479–789 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809465 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
HIF-1 beta (ARNT) is part of the aryl hydrocarbon receptor nuclear translocator gene family. It plays a critical role in mammalian oxygen homeostasis and forms a heterodimer with HIF-1 alpha.
Under normoxic conditions, HIF-1 alpha is hydroxylated and degraded, while HIF-1 beta remains stable.
Under hypoxic conditions, HIF-1 alpha accumulation leads to increased transcriptional activity.
Associated Diseases:
- Hypoxia
- Renal cell carcinoma
- Myocardial and cerebral ischemia
- Cancer
- Pulmonary hypertension
- Congenital heart disease
- Chronic obstructive pulmonary disease
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- MA5-32177_HIF-1_beta_P27540-1_Rabbit.svg
- MA5-32177_HIF-1_beta_P27540-1_Rabbit_PDP.jpeg
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