Thermo Fisher Scientific HIF-1 beta Recombinant Rabbit Monoclonal Antibody (ST05-25)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

HIF-1 beta (ARNT) is part of the aryl hydrocarbon receptor nuclear translocator gene family. It plays a critical role in mammalian oxygen homeostasis and forms a heterodimer with HIF-1 alpha.
Under normoxic conditions, HIF-1 alpha is hydroxylated and degraded, while HIF-1 beta remains stable.
Under hypoxic conditions, HIF-1 alpha accumulation leads to increased transcriptional activity.

Associated Diseases:

• Hypoxia
• Renal cell carcinoma
• Myocardial and cerebral ischemia
• Cancer
• Pulmonary hypertension
• Congenital heart disease
• Chronic obstructive pulmonary disease

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

• MA5-32177_HIF-1_beta_P27540-1_Rabbit.svg
• MA5-32177_HIF-1_beta_P27540-1_Rabbit_PDP.jpeg