Thermo Fisher Scientific Chk1 Recombinant Rabbit Monoclonal Antibody (ST57-09)
Chk1 단백질을 인식하는 재조합 토끼 단일클론 항체로 높은 특이성과 민감도를 제공. Western blot 및 면역세포염색에 적합. HEK293 세포 발현 시스템 사용으로 로트 간 일관성 유지. 연구용으로 DNA 손상 반응 및 세포주기 조절 연구에 활용 가능.
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Thermo Fisher Scientific Chk1 Recombinant Rabbit Monoclonal Antibody (ST57-09)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ST57-09 |
| Immunogen | Synthetic peptide within Human Chk1 (aa 431–476) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2809468 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase that prevents replication when DNA integrity is compromised. It acts as a key mediator in the DNA damage-induced checkpoint network and maintains genomic integrity under genotoxic stress.
Inhibition of CHK1 can lead to mitotic catastrophe and apoptosis in p53-deficient cancer cells, while normal cells remain arrested in G1 phase.
Thus, CHK1 represents an attractive therapeutic target for cancer treatment, particularly in p53-deficient tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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