Thermo Fisher Scientific CD63 Monoclonal Antibody (M034)

Applications

Product Specifications

Product Specific Information

Clone M034 mouse monoclonal antibody detects a 30–60 kDa protein on SDS-PAGE native immunoblots of human A549, MeWo, MDA-MB-231, and MCF7 cells, as well as human breast, lung, and skin tissues.
This antibody does not detect denatured CD63.
Applicable for western blot, immunoprecipitation, ELISA capture, and immunocytochemistry.

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family, found in late endosomes, lysosomes, and secretory vesicles of various cell types. It is also present in the plasma membrane following cell activation and serves as a basophil activation marker.
CD63 interacts with integrins and affects phagocytosis and cell migration. It is involved in H/K-ATPase trafficking and ROMK1 channel regulation, and acts as a T-cell costimulation molecule.
CD63 expression can be used for prognosis in early-stage carcinomas. It is expressed on activated platelets, monocytes, macrophages, and weakly on granulocytes, B, and T cells.
CD63 is identical to the melanoma-associated antigen ME491 and the platelet antigen PTLGP40.
Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.