Thermo Fisher Scientific Phospho-HDAC8 (Ser39) Polyclonal Antibody
HDAC8 단백질의 Ser39 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 고순도 정제, PBS/glycerol 저장, 연구용 전용 제품.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HDAC8 (Accession Q9BY41), corresponding to amino acid residues around phosphorylated Ser39 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816504 |
Product Specific Information
This antibody detects endogenous levels of HDAC8 only when phosphorylated at Serine 39.
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is a key component of transcriptional regulation, driven largely by histone acetylation. Acetylation of lysine residues in histone tails increases DNA accessibility to transcription factors, whereas deacetylation is associated with transcriptional silencing. Mammalian HDAC8, isolated from human kidney, is a nuclear histone deacetylase sharing homology with other HDACs but showing distinct tissue distribution. HDAC8 plays a role in tissue development and cancer etiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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