Thermo Fisher Scientific Phospho-FANCD2 (Ser222) Polyclonal Antibody
FANCD2 단백질의 Ser222 인산화 형태를 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합. 인간, 생쥐, 랫드 반응성. 고순도, 액상 형태, 연구용으로 DNA 복구 관련 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human FANCD2 (Accession Q9BXW9), corresponding to amino acid residues around phosphorylated Ser222 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816503 |
Product Specific Information
This antibody detects endogenous levels of FANCD2 only when phosphorylated at Serine 222.
Target Information
FANCD2 (Fanconi anemia group D2 protein) is essential for maintaining chromosomal stability and promotes accurate pairing of homologs during meiosis. It participates in DNA double-strand break repair through homologous recombination and single-stranded annealing. FANCD2 stabilizes BLM under replicative stress and facilitates BRCA2/FANCD1 loading onto damaged chromatin. Mutations in FANCD2 cause Fanconi anemia complementation group D2, leading to bone marrow failure and cytopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-105030_FANCD2_Q9BXW9-2_Rabbit.svg, PA5-105030_FANCD2_Q9BXW9-2_Rabbit_PDP.jpeg)
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