![Thermo Fisher Scientific Human LRRK2 [G2019S], GST Tag Recombinant Protein](https://images.cacheby.com/product-images/cacheby/16d923d0-28bb-11f0-94c0-7d6515e368de/CellBioRecProtInvitrogenVial.jpg-650.jpg)
Thermo Fisher Scientific Human LRRK2 [G2019S], GST Tag Recombinant Protein
인간 LRRK2 G2019S 변이 GST 태그 재조합 단백질로 파킨슨병 연구용 키나아제 분석에 적합. 곤충세포 발현, 고순도 정제, -80°C 보관. 연구 전용 제품으로 안정적 활성 유지 및 다양한 키나아제 분석에 활용 가능.
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Thermo Fisher Scientific Human LRRK2 [G2019S], GST Tag Recombinant Protein
Applications
- Kinase Assay (KA)
Tested Dilution: Assay-dependent
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | 970-2527; G2019S |
| Tag | GST-tag |
| Molecular Weight | 204.9 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris, pH 7.5, with 0.02% polysorbate 20, 50% glycerol, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, please spin prior to use.
- Aliquots of the 5 µg, 10 µg, and 20 µg sizes are not recommended; use in original packaging until exhausted.
- For larger sizes, aliquot preparation may reduce freeze/thaw cycles (avoid aliquots below 20 µL).
- Do not store kinase diluted.
- Properly stored at -80°C, product is guaranteed for 6 months from date of purchase.
Protein Form: Recombinant, Catalytic, Mutant
Target Information
LRRK2 (Leucine Rich Repeat Kinase 2) is a protein-coding gene.
Diseases associated with LRRK2 include Parkinson Disease 8 (Autosomal Dominant) and Hereditary Late-Onset Parkinson Disease.
Related pathways include:
- Signaling by PTK6
- ncRNAs involved in Wnt signaling in hepatocellular carcinoma
Gene Ontology (GO) annotations:
- Protein homodimerization activity
- Transferase activity (transferring phosphorus-containing groups)
An important paralog of LRRK2 (G2019S Mutant) is TNNI3K.
Mutations in the LRRK2 gene are known as the most common genetic cause of late-onset autosomal-dominant Parkinson’s disease.
Related Links
- LRRK2 tools for advancing Parkinson’s disease research
- Kinase protein portfolio
- [LanthaScreen™ Eu Kinase Binding Assay](http://www.invitrogen.com/site/us/en/home/Products-and-Services/Applications/Drug-Discovery/Target-and-Lead-Identification-and-Validation/Kinase Biology/Kinase-Activity-Assays/lanthascreentm-eu-kinase-binding-assay.html)
- [LanthaScreen™ Activity Assay](http://www.invitrogen.com/site/us/en/home/Products-and-Services/Applications/Drug-Discovery/Target-and-Lead-Identification-and-Validation/Kinase Biology/Kinase-Activity-Assays/LanthaScreen-TR-FRET-ToolBox.html)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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