Thermo Fisher Scientific Human JAK1, GST Tag Recombinant Protein

Thermo Fisher Scientific Human JAK1, GST Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
• For larger sizes, aliquots may reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
• Do not store kinase diluted.
• Properly stored at -80°C, product is guaranteed for 6 months from purchase.

Protein Form: Recombinant, Cytoplasmic, Catalytic

Target Information

Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in interferon-α/β and -γ signal transduction pathways. Immunological stimuli such as interferons and cytokines recruit Stat transcription factors to cytokine receptor-associated JAK1. JAK1 phosphorylates proximal Stat factors, which then dimerize, translocate to the nucleus, and regulate gene transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and activation; phosphorylation at residues 1022 and 1023 is key to catalytic activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.