Thermo Fisher Scientific Human JAK1, GST Tag Recombinant Protein
인간 JAK1 단백질을 GST 태그로 발현한 재조합 단백질로, 키나아제 활성 분석에 적합합니다. 곤충 세포에서 발현되었으며, 고순도 정제된 액상 형태입니다. -80°C에서 보관하며, 연구용으로만 사용됩니다.
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- 판매단위
- pk
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Thermo Fisher Scientific Human JAK1, GST Tag Recombinant Protein
Applications
- Kinase Assay (KA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | 866–1154 |
| Tag | GST-tag |
| Molecular Weight | 60.8 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris (pH 7.5), 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 0.02% Triton X-100, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, spin prior to use.
- Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
- For larger sizes, aliquots may reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
- Do not store kinase diluted.
- Properly stored at -80°C, product is guaranteed for 6 months from purchase.
Protein Form: Recombinant, Cytoplasmic, Catalytic
Target Information
Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in interferon-α/β and -γ signal transduction pathways. Immunological stimuli such as interferons and cytokines recruit Stat transcription factors to cytokine receptor-associated JAK1. JAK1 phosphorylates proximal Stat factors, which then dimerize, translocate to the nucleus, and regulate gene transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and activation; phosphorylation at residues 1022 and 1023 is key to catalytic activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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