Thermo Fisher Scientific HMGCR Polyclonal Antibody
HMGCR 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트 반응성. Western blot, IHC, ICC 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제된 고순도 시약으로, 콜레스테롤 생합성 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 | View 9 publications |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length human HMGCR (UniProt ID: P04035-1, range 1–888, length 888) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2554032 |
Product Specific Information
This antibody detects endogenous HMGCR protein at a molecular weight of approximately 97 kDa.
Purity is >95% by SDS-PAGE.
Target Information
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, essential for the biosynthesis of cholesterol and other isoprenoids. It catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in cholesterol production.
HMGCR is the primary target of statin drugs, which lower cholesterol levels and reduce cardiovascular disease risk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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