Thermo Fisher Scientific ATF4 Monoclonal Antibody ([N360A/24)
ATF4 단백질을 검출하기 위한 Mouse IgG2a 단클론 항체로, Human, Mouse, Rat에서 반응합니다. WB, IHC, ICC 등 다양한 응용에 적합하며, Protein G 정제 및 PBS/glycerol buffer로 안정화되었습니다. 약 60kDa 단백질 검출에 유용하며 ATF5와 교차반응하지 않습니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N360A/24 |
| Immunogen | Fusion protein amino acids 25–327 of human ATF4. 86% identical to rat, 85% identical to mouse, <50% identity with ATF5. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735121 |
Additional Formats
Product Specific Information
1 µg/mL of MA5-27721 was sufficient for detection of ATF4 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 60 kDa. Does not cross-react with ATF5.
This antibody was formerly sold as clone S360A-24.
Target Information
This gene encodes a transcription factor originally identified as a widely expressed mammalian DNA-binding protein that binds a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also characterized as cAMP-response element binding protein 2 (CREB-2).
The ATF4 protein belongs to a family of DNA-binding proteins including AP-1, CREBs, and CREB-like proteins, sharing a leucine zipper region for protein-protein interactions and a basic amino acid stretch functioning as a DNA-binding domain.
Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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