Thermo Fisher Scientific alpha-2c Adrenergic Receptor Monoclonal Antibody (N330A/80)
Alpha-2C 아드레날린 수용체를 특이적으로 인식하는 mouse monoclonal antibody로, WB, ICC/IF, IHC(F) 등에 사용 가능. 인간과 생쥐에 반응하며 단백질 G로 정제된 액상 형태. 고감도 검출 및 교차 반응 최소화. 연구용으로만 사용.
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Thermo Fisher Scientific Alpha-2C Adrenergic Receptor Monoclonal Antibody (N330A/80)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Frozen) (IHC(F)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N330A/80 |
| Immunogen | Synthetic peptide amino acids 442–462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735109 |
Additional formats available:
Product Specific Information
1 µg/mL of MA5-27724 was sufficient for detection of Alpha-2C Adrenergic Receptor in 20 µg of COS cells transiently transfected with HA-tagged Alpha-lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Detects 50 kDa or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.
This antibody was formerly sold as clone S330A-80.
Target Information
Alpha-2-adrenergic receptors belong to the G protein-coupled receptor superfamily and include three subtypes: alpha2A, alpha2B, and alpha2C.
These receptors regulate neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system.
In mice, alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release.
Alpha2A inhibits release at high stimulation frequencies, while alpha2C modulates neurotransmission at lower activity levels.
This gene encodes the alpha2C subtype, containing no introns in its coding or untranslated sequences.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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