Thermo Fisher Scientific PTGES3 Monoclonal Antibody (OTI3A9), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences after activation by the appropriate hormone.
Before activation, steroid receptors associate with various proteins, including heat shock proteins (HSP70, HSP90), immunophilins (FKBP52, FKBP54, CyP-40), and other proteins such as p23, p60, and p48.

p23, along with HSP70, HSP90, and p60, forms a transient intermediate complex with progesterone receptor (PR).
Human p23 encodes a 160 amino acid protein highly conserved between species and is a highly acidic phosphoprotein with multiple potential phosphorylation sites.
It binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR, playing an essential role in PR function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.