Thermo Fisher Scientific TMED10/TMP21 Polyclonal Antibody
TMED10/TMP21 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB와 IP에 적합합니다. 인간 및 생쥐 반응성이 있으며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C에서 보관합니다.
- 카탈로그번호
- A305219A
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 169–219 of Human Transmembrane emp24 domain-containing protein 10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Rabbit, Golden hamster, and Orangutan
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is a component of the presenilin complex and modulates γ-secretase but not ε-secretase cleavage activity of amyloid precursor protein. The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1, which together cleave the amyloid precursor protein at γ- and ε-sites, leading to Abeta accumulation associated with Alzheimer’s disease. Co-immunoprecipitation experiments indicate TMP21 may regulate this complex. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating its modulatory role.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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