Thermo Fisher Scientific TMED10/TMP21 Polyclonal Antibody
Rabbit polyclonal antibody targeting human TMED10/TMP21 protein. Validated for Western blot and immunoprecipitation. Predicted cross-reactivity with multiple species. Supplied as liquid, 1 mg/mL concentration, stored at 4°C. For research use only.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TMED10/TMP21 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 169 to 219 of Human Transmembrane emp24 domain-containing protein 10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Rat, Bovine, Rabbit, Golden hamster, and Orangutan
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is a component of the presenilin complex and modulates the γ-secretase—but not the ε-secretase—cleavage activity of the amyloid precursor protein. This complex includes APH1, nicastrin, PEN2, and presenilin-1, which cleave amyloid precursor protein at γ- and ε-sites, potentially leading to accumulation of Abeta, associated with Alzheimer’s disease. Co-immunoprecipitation experiments have shown TMP21’s association with these proteins, suggesting a regulatory role. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating TMP21’s modulatory function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.