Thermo Fisher Scientific APBA2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

-

Immunoprecipitation (IP)

2-10 µg/mg lysate

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 125 to 175 of human Amyloid beta A4 precursor protein-binding family A member 2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:APBA2,uniProtId:Q99767-1,ncbiNodeId:9606,antigenRange:125-175,antigenLength:749,antigenImageFileName:A305-220A_APBA2_Q99767-1_Rabbit.svg,antigenImageFileNamePDP:A305-220A_APBA2_Q99767-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

phosphate/tris citrate, pH 7-8

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Wet ice

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimers disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimers disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.