Thermo Fisher Scientific TMED10/TMP21 Polyclonal Antibody
Human 및 Mouse 반응성을 가진 Rabbit Polyclonal TMED10/TMP21 항체로, WB 및 IP에 사용 가능. 액상 형태(1 mg/mL)로 항원 친화 크로마토그래피로 정제됨. TMP21 단백질의 γ-secretase 조절 연구에 적합한 연구용 시약.
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Applications
- Western Blot (WB): 1:2,000–1:10,000
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25–75 of Human Transmembrane emp24 domain-containing protein 10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | BBS, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Orangutan
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is a component of the presenilin complex and modulates γ-secretase activity, but not ε-secretase cleavage of the amyloid precursor protein.
The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1, which together cleave amyloid precursor protein at γ- and ε-sites, leading to Abeta accumulation associated with Alzheimer’s disease.
Co-immunoprecipitation experiments indicate TMP21 participates in regulating this complex. Suppression of TMP21 via siRNA increases γ-secretase activity and Abeta production, showing TMP21’s modulatory role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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