Thermo Fisher Scientific TMED10/TMP21 Polyclonal Antibody
Rabbit polyclonal antibody targeting human TMED10/TMP21, suitable for WB and IP applications. Recognizes residues 25–75 of TMP21. Supplied as unconjugated liquid (1 mg/mL), stored at 4°C, shipped on wet ice. Predicted cross-reactivity with orangutan; 1...
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25–75 of Human Transmembrane emp24 domain-containing protein 10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is a component of the presenilin complex and modulates γ-secretase but not ε-secretase cleavage activity of the amyloid precursor protein.
The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1. Together, these proteins cleave the amyloid precursor protein at γ- and ε-sites, leading to accumulation of the Abeta cleavage product associated with Alzheimer’s disease.
Co-immunoprecipitation experiments indicate that TMP21 may regulate this complex. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating TMP21’s modulatory role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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