Thermo Fisher Scientific TMED10/TMP21 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Target Information

TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is a component of the presenilin complex and modulates γ-secretase but not ε-secretase cleavage activity of the amyloid precursor protein.
The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1. Together, these proteins cleave the amyloid precursor protein at γ- and ε-sites, leading to accumulation of the Abeta cleavage product associated with Alzheimer’s disease.
Co-immunoprecipitation experiments indicate that TMP21 may regulate this complex. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating TMP21’s modulatory role.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.