Thermo Fisher Scientific beta Arrestin 1 Recombinant Rabbit Monoclonal Antibody (ST51-08)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed in HEK293 cells. Individual clones are screened to select optimal candidates for production.

Advantages:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the rabbit immune repertoire

Target Information

Beta Arrestin 1 is a member of a protein family widely expressed and abundant in the central nervous system. It functions as an adaptor or scaffold molecule essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of G protein-coupled receptors (GPCRs), such as the beta 2-adrenergic receptor.

After ligand binding and G protein interaction, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1, phosphorylated by ERK1/2 on serine 412, binds to phosphorylated receptors at the plasma membrane. Subsequent dephosphorylation of serine 412 leads to GPCR internalization and activation of the Ras–Raf–ERK1/2 signaling pathway.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.