Thermo Fisher Scientific Phospho-M2 Muscarinic Acetylcholine Receptor (Thr310, Ser311) Polyclonal Antibody
인간 M2 무스카린 아세틸콜린 수용체의 Thr310/Ser311 인산화 부위에 특이적인 폴리클로날 항체. Western blot에 적합하며 항원 친화 크로마토그래피로 정제됨. 액상 형태로 1 mg/mL 농도, 장기 보관 시 -20°C 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: [참조 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human M2 around the phosphorylation site of Thr310/Ser311 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Muscarinic cholinergic receptor 2 (CHRM2) is an acetylcholine receptor suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor is also implicated in smooth muscle contractility.
In Alzheimer’s disease, selective loss of M2 subtype receptors occurs in cortical and hippocampal regions. Increased M2 receptor heterozygosity has been associated with depression in women.
The M2 receptor is expressed in various brain regions including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, as well as in lung and prostate tissues.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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