Thermo Fisher Scientific Phospho-M2 Muscarinic Acetylcholine Receptor (Thr271) Polyclonal Antibody
사람 유래 M2 무스카린 아세틸콜린 수용체 Thr271 인산화 부위를 인식하는 토끼 다클론 항체. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human M2 around the phosphorylation site of Thr271 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Muscarinic cholinergic receptor 2 (CHRM2) is an acetylcholine receptor that functions as a presynaptic autoreceptor inhibiting acetylcholine release. The M2 receptor is also involved in smooth muscle contractility.
In Alzheimer’s disease, selective loss of M2 subtype receptors occurs in cortical and hippocampal regions of the human brain. Increased M2 receptor heterozygosity has been associated with depression in women.
The M2 receptor is expressed in various brain regions including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, as well as in lung and prostate tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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