Thermo Fisher Scientific Phospho-PLCg2 (Tyr759) Recombinant Rabbit Monoclonal Antibody (PLCG2Y759-G3)

Applications

Western Blot (WB)

• Assay-dependent

Flow Cytometry (Flow)

• 1–1,000 ng/mL

Product Specifications

Additional Formats

• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to the large rabbit immune repertoire

Target Information

Phosphoinositide-specific phospholipase C (PLC) plays a key role in receptor-mediated signal transduction by generating two second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate.
There are multiple mammalian PLC isozymes including PLCβ1–4, PLCγ1–2, PLCδ1–2, and PLCε.
PLCδ isoforms, particularly PLCδ1, act as calcium signal amplifiers and are involved in oxytocin receptor and α1B-adrenoreceptor signaling. Abnormal accumulation of PLCδ has been observed in Alzheimer’s disease brains, suggesting a potential role in AD pathology.
PLCδ2 expression is associated with intestinal metaplasia and adenocarcinoma, serving as a potential marker for gastric malignant transformation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.