Thermo Fisher Scientific Phospho-PLCg2 (Tyr759) Recombinant Rabbit Monoclonal Antibody (PLCG2Y759-G3)
Phospho-PLCγ2 (Tyr759)을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 유세포분석에 적합합니다. 높은 특이성과 민감도를 제공하며, 로트 간 일관성과 동물유래 성분이 없는 포뮬레이션을 특징으로 합니다.
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Applications
Western Blot (WB)
- Assay-dependent
Flow Cytometry (Flow)
- 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PLCG2Y759-G3 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCγ2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745039 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the large rabbit immune repertoire
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a key role in receptor-mediated signal transduction by generating two second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate.
There are multiple mammalian PLC isozymes including PLCβ1–4, PLCγ1–2, PLCδ1–2, and PLCε.
PLCδ isoforms, particularly PLCδ1, act as calcium signal amplifiers and are involved in oxytocin receptor and α1B-adrenoreceptor signaling. Abnormal accumulation of PLCδ has been observed in Alzheimer’s disease brains, suggesting a potential role in AD pathology.
PLCδ2 expression is associated with intestinal metaplasia and adenocarcinoma, serving as a potential marker for gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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