Thermo Fisher Scientific LGMN Recombinant Rabbit Monoclonal Antibody (ARC1864)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC1864

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 210-302 of human Legumain (LGMN) (Q99538) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LGMN,uniProtId:Q99538-1,ncbiNodeId:9606,antigenRange:210-302,antigenLength:433,antigenImageFileName:MA5-38162_LGMN_Q99538-1_Rabbit.svg,antigenImageFileNamePDP:MA5-38162_LGMN_Q99538-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898079

Product Specific Information

Positive Samples: 293T, HepG2, MCF7, Mouse brain, Mouse spleen, Mouse kidney

Immunogen sequence: ANPRESSYAC YYDEKRSTYL GDWYSVNWME DSDVEDLTKE TLHKQYHLVK SHTNTSHVMQ YGNKTISTMK VMQFQGMKRK ASSPVPLPPV THL

Target Information

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.