Thermo Fisher Scientific ZNRF2 Polyclonal Antibody
ZNRF2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot에 적합하며, 인간, 생쥐, 랫드 시료에 반응. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 연구용으로 사용 가능.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 155–200 of Human ZNRF2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719663 |
Product Specific Information
This antibody was affinity-purified from rabbit antiserum by epitope-specific affinity chromatography. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Ubiquitination is a key mechanism involving three enzyme classes—E1 (ubiquitin-activating), E2 (ubiquitin-conjugating), and E3 (ubiquitin-protein ligase)—that collaborate to degrade short-lived or abnormal proteins.
ZNRF2 (Zinc and Ring Finger 2), also known as RNF202, is a 242-amino-acid peripheral membrane protein containing a RING-type zinc finger. It localizes to lysosomes, endosomes, and cell junctions, and is highly expressed in brain tissue. ZNRF2 functions as an E3 ubiquitin ligase, potentially contributing to neuronal transmission and plasticity. Upon DNA damage, it undergoes phosphorylation, likely mediated by ATR or ATM.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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