Thermo Fisher Scientific CD85g (ILT7) Monoclonal Antibody (eBio17G10.2 (17G10.2)), PE, eBioscience
인간 ILT7(CD85g)을 인식하는 마우스 단클론 항체로, PE 형광 표지되어 있습니다. Flow Cytometry 분석에 최적화되어 있으며, pDC 특이적 발현 확인에 사용됩니다. 4°C 암소 보관, 동결 금지. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific CD85g (ILT7) Monoclonal Antibody (eBio17G10.2 (17G10.2)), PE, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry | 5 µL (0.125 µg)/test | View 2 publications |
| Functional Assay | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio17G10.2 (17G10.2) |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10852713 |
Additional Formats
- APC
- Functional Grade
- PerCP-Cyanine5.5
- Request custom conjugation
Product Specific Information
The eBio17G10.2 monoclonal antibody reacts with human immunoglobulin-like transcript 7 (ILT7), also known as CD85g. ILT7 is part of the leukocyte immunoglobulin-like receptor (LIR) gene family and associates with Fc epsilon R1 gamma to form a functional complex that transduces ITAM-mediated signals, negatively modulating TLR-induced type I IFN production by human plasmacytoid dendritic cells (pDCs).
ILT7 is expressed exclusively on pDCs and is absent in monocyte-derived DCs. Treatment with IL-3 or CpG reduces expression.
Double staining of human PBMCs with eBio17G10.2 and anti-pDC marker BDCA2 shows nearly complete co-staining. Crosslinking ILT7 with eBio17G10.2 antibody reduces transcription of IFN alpha1, alpha2, alpha4, and beta.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested for flow cytometric analysis of normal human peripheral blood cells. Recommended usage: 5 µL (0.125 µg) per test (100 µL final volume). Cell number may vary from 10⁵ to 10⁸ cells/test.
Excitation: 488–561 nm; Emission: 578 nm; Laser: Blue, Green, Yellow-Green.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
ILT7 is a pDC-specific IgG-like transcript and member of the leukocyte immunoglobulin-like receptor gene family. In complex with FcER1a, it transduces ITAM-mediated signals that negatively modulate type I IFN production by pDCs. ILT7 is a potential target to regulate Type I IFN production, relevant in viral infection, autoimmune disease, and anti-cancer immunity.
ILT7, along with CD123 and BDCA-2, can be used to identify or classify subsets of pDCs and study TLR expression and TLR-mediated immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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