Thermo Fisher Scientific Calprotectin/MRP14/S100A9/Calgranulin B Monoclonal Antibody (S100A9/1011)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises about 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages, and ileal tissue eosinophils.
Peripheral blood monocytes carry the antigen both extra- and intracellularly, while neutrophils contain it only intracellularly. The S100A8/A9 complex exhibits antibacterial, antifungal, immunomodulating, and antiproliferative properties, and serves as a potent chemotactic factor for neutrophils.
Plasma concentrations are elevated in diseases associated with increased neutrophil activity, such as inflammatory bowel disease. Calprotectin can also be detected in feces due to granulocyte transmigration through the intestinal wall. Elevated levels have been observed in plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.