Thermo Fisher Scientific Human Factor XIII Native Protein
Native human Factor XIII 단백질로 면역학적 분석의 양성 대조군으로 사용 가능. 혈액 응고 관련 연구에 적합하며, SDS-PAGE로 정제된 고순도 제품. 인체 유래 시료로 제조되어 -20°C에서 보관하며 반복 동결/해동을 피해야 함.
- 카탈로그번호
- RP43077
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
- Control (Ctrl): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Molecular Weight | 320 kDa |
| Class | Native |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 6.1 mg/mL |
| Purification | SDS-PAGE |
| Storage Buffer | 50% glycerol, 0.5M EDTA |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
RP-43077 contains native human Factor XIII protein.
RP-43077 may be used as a positive control in many immunological assays.
The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process and found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore, and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests.
This product is to be used for IN VITRO research purposes only and is not intended for clinical or diagnostic use.
Target Information
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits lack enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII consists only of two A subunits, identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme factor XIIIa, identical to platelet factor XIII.
This enzyme acts as a transglutaminase to catalyze gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin.
Factor XIII deficiency is categorized into:
- Type I deficiency: lack of both A and B subunits
- Type II deficiency: lack of the A subunit only
These defects can result in lifelong bleeding tendency, defective wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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