Thermo Fisher Scientific ATM Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: -

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000
• Publications: -

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Dog (84%), Pig (81%), Bovine (82%).
• Positive Control: HeLa, HeLa NE.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein in the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins rather than lipids and has downstream targets acting as cell-cycle regulators, including P53, Mdm2, BRCA1, and SMC1.
ATM repairs double-stranded DNA breaks caused by ionizing radiation and mutagens. Its C-terminal region shares homology with catalytic domains of PI3 kinases.
ATM becomes autophosphorylated and upregulated upon exposure to ionizing radiation. AT cells are hypersensitive to radiation, impaired in DNA synthesis inhibition, and delayed in p53 induction.
DNA damage activates ATM-kinase, triggering a cascade of kinase reactions regulating cell cycle, apoptosis, and DNA damage repair. Studies link ATM with apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.